Since cortison was administered to various clinical conditions, a large number of reports reviewed the influence of its application on the repair process of connective tissue.
The effect of cortisone was described as consisting of delayed formation of fibroblast, mucopolysaccharide and collagen, depressed activity of vitamin D in the human body, disturbed calcium metabolism and consequently the delayed healing of the fracture.
And it was therefore decided to investigate the effect of cortisone on fracture healing process. Twenty male rabbits weighing between 1500 and 2000 gms were used for this experiment. Their ribs were fratured and they were divided in 4 groups as follows: Ist group: control group
2nd group: vitamin. C 15mg/Kg. daily I. M.
3rd group: cortione acetate 20mg/Kg. daily I. M.
4th group: cortisone acetate 20mg/Kg. with vitamin. C 15mg/Kg. daily I. M.
Gross and histological changes of healing process of ribs were observed, and results confirmed the delaying effect of cortisone administration in the fracture healing, on the contrary, the vitamin. C administration seemed to accelerate.
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